Several Years ago, I was approached by a potential physician-client asking me to incorporate CBD into a topical gel intended for pain management. I remember asking, “What is CBD?” At that time, I had never had a conversation regarding CBD or the endocannabinoid system with any docs or any patients. How times have changed! Now I have a conversation with patients and docs daily – and they bring up the topic!
What is CBD?
CBD, scientifically known as cannabidiol, is one of over 500 molecules found in marijuana and hemp. It has no psychogenic effects, and presents minimal at no side effects, and presents minimal to no side effects as reported by scientific and medical literature, even at high doses. Another molecule of marijuana, THC, scientifically known as tetrahydrocannabinol, presents numerous documented side effects including well0known psychogenic effects.
Both hemp and marijuana belong to the Cannabis Sativa plant species. They differ in appearance and have different scientific properties. Physically, hemp is a taller, skinnier plant with narrow leaves primarily at the top of the plant. Marijuana is of a shorter, more bush-like stature with dense buds and broad leaves. THC is heavily present in marijuana while CBD is minimal; hemp has virtually no THC with an abundance of CBD. Because of its THC content, marijuana is primarily grown for its psychoactive properties. Hemp is grown for a variety of THC-free products like paper, clothing, biofuels, food products, and oils. We now understand
that hemp can be grown to extract CBD.

The Endocannabinoid System

Thirty years ago, when I was in podiatric medical school, there was no instruction regarding the endocannabinoid system. Today, roughly one of seven general medical schools add the endocannabinoid system to the curriculum, typically part of one lecture. The endocannabinoid system was initially described by Raphel Mechoulam after he discovered anandamide, a naturally occurring endogenous cannabinoid (endocannabinoid) (Figure 19. The human body produces its own cannabinoids and cannabinoid receptors. The receptors have been discovered in the central nervous system in humans as early as intrauterine fetuses at 5 months! And more recently, studies confirm cannabinoids in human breast milk.

The endocannabinoid system is comprised of cannabinoid receptors called CB1 and CB2, endocannabinoid molecules (like anandamide), and their metabolic proteins. It primarily functions to support and maintain homeostasis in the body. CB1 receptors are located throughout the body in the central nervous system and primarily the brain. CB2 receptors are also located throughout the body with a heavy concentration found in peripheral organs associated with our immune system (Figure 2(. 95% of CB1 and CB2 neural receptors are GABAergic, meaning CBD cannabidiol acts on receptors that use GABA (gama-aminobutyric acid; 4-aminobutyric acid) as the neurotransmitter. GABA receptors are associated with transmission of pain (Figure 3).
We can help manage pain with CBD applied topically and taken systemically (oral or sublingual) without the side effects of opiates.Persoanl Experience
Let me preface these clinical observations and my own experiences. Like you I essentially doubt anything I am told about efficacy of anything in treating painful conditions – especially any product claiming relief of pain when applied topically. My “clinical trials” include me simply handing patients a blank tube of gel (Orthonesic with 25milligrams of cannabidiol) and asking that they try it on the area in pain. I hand the patient a tube and leave the treatment room about ten minutes while seeing other patients. Every single patient-without exception – experienced immediate pain relief.

This observation extends to neuroma pain, myotendinous calf pain, OCL talus ankle pain, bunion pain, and trauma closed wounds. I even gave some of my orthopedist co-workers the non-opioid CBD gel and they also eradicated their patient’s painful pathologies.

As physicians prescribing medication, we are warned of danger of opioids and daily overdoses reported nationwide. But we are not being told about non-addictive and self alternatives. Mu personal experiences with administrating CBD both topically and sublingually have allowed me to manage pain and minimise patient use of opiates. When I do write for an opioid, I have had great success with 2.5 mg of oxycodone taken with 25mg of sublingual CBD. Pain is relieved while the risk of addiction is drastically diminished. By using safe, effective, and naturally occurring opioid alternatives, we can save patients from pain and addiction.

Dr. Robert Blaine serves as Chief Medical Officer for Vivera Pharmaceuticals and is a member of the Executive Board of Vevera Pharmaceuticals. Prior to joining Vivera, Dr. Blaine gained 22 years of experience as the founder and CEO of Blaine Labs, a pharmaceutical research, development, manufacturing, and distribution company. Dr. Blaine began his career as a podiatric surgeon specialising in lower extremity trauma, and has over thirty years of medicine and surgical experience. He served as the Podiatric Surgical Residency Director at Bellwood General Hospital for eight years. Dr. Blaine holds a podiatric medical degree from the California College of PodiatricMedicine, and a Bachelor of Science in Biology and Chemistry from California State University. He completed graduate work in Biochemistry at University of California.

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